Revolutionary Discovery : End of fillings in sight as scientists find Alzheimer’s drug makes teeth grow back

We could repair our damaged teeth by our self in the future, which would mean the end for sick visits to the dentist and placing fillings, say British scientists which have created a drug that successfully repaired the holes in the teeth of mice.

Teeth already have the capability of regenerating dentine if the pulp inside the tooth becomes exposed through a trauma or infection, but can only naturally make a very thin layer, and not enough to fill the deep cavities caused by tooth decay.

But Tideglusib switches off an enzyme called GSK-3 which prevents dentine from carrying on forming.

Scientists showed it is possible to soak a small biodegradable sponge with the drug and insert it into a cavity, where it triggers the growth of dentine and repairs the damage within six weeks.

The tiny sponges are made out of collagen so they melt away over time, leaving only the repaired tooth.




In the standard treatment of dental caries, the visit to the dentist means digging in a broken tooth with small tools and using mixtures of metals or composites consisting of ceramic powder and glass. In both cases, often in our life we need several times to change such fillings as they perish.

But, back to the application of “Tideglusib”. Once scientists placed the biodegradable sponge soaked in the drug in the damaged part of the tooth they have also added protective layer trough it. By the time biodegradable sponge in the tooth disappears, the drug does its job, and the tooth is completely cured without no hole.

“The space in which it was located sponge full of minerals during the breakdown and regeneration of the tooth, and so in the future there will be nothing that can be damaged such as the fillings,” said Professor Paul Sharpe, who participated in the above mentioned research.

Also, Sharp believes that the drug could be on the market within three to five years.

It is interesting that “Tideglusib” changes series of signals in cells that are called “Wnt” and are implicated in some cancers. Also this drug has already been tested on patients as a potential treatment for dementia.




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